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In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Jodi Duval, and Dr. Ted Achacoso give us one-cent solutions to life’s $64,000 questions that include:
\n

What is the cell danger response, and how does it function as an evolutionarily conserved survival mechanism rather than a disease?
Why does the body prioritize protection and inflammation first, before repair and full resolution?
How do the three stages of the cell danger response shape clinical outcomes when the body becomes “stuck” in one phase?
Why can common interventions like antioxidants, fasting, or supplements backfire when applied at the wrong stage?
How does identifying and removing the underlying threat change the trajectory of healing and health optimization?

What We Discuss:

00:00 Intro: What Is the Cell Danger Response?
01:30 Dr. Robert Naviaux & the Origin of CDR
03:00 CDR Stage 1: Defense, Inflammation & Survival
05:30 Mitochondria as Sensors (Not Just Batteries)
07:30 ATP Signaling & Cellular Danger Alerts
10:00 Why Suppressing Inflammation Can Backfire
12:00 CDR Stage 2: Repair, Growth & Proliferation
15:30 Chronic Disease as “Stuck” CDR (Cancer, Diabetes)
18:30 Gut Health, Hormones & CDR2 Dysfunction
21:30 CDR Stage 3: Resolution & Reintegration
24:00 Chronic Fatigue & Being Stuck in CDR3
26:30 Why You Must Remove the Threat First
29:00 What Clinicians Should (and Should NOT) Do
31:30 Final Takeaways: Survival, Stall & Mitochondria

Full Transcript:

Boomer Anderson: [00:00:00] Welcome back everybody to another episode of the Health Optimization Medicine podcast. Uh, today we have Jody Duval. We have Dr. Ted and myself. Uh, for those of you who are tuning into this on YouTube Smile, we're saying hi to you. Uh, but also for those of you listening on Apple Podcasts or Spotify, please.\n\nBoomer Anderson: Like, subscribe, meet comments, all the fun stuff. We're gonna dive into so many fun things today. And perhaps my new, well not to, it's not really a new concept, but my new favorite topic within um, health optimization medicine is the cell danger response. Uh, perhaps because it's had a very profound effect in my own journey.\n\nBoomer Anderson: I don't wanna say healing journey 'cause that's too California. Uh, but today we're gonna talk about the cell danger response and we're gonna go, uh, we're gonna kind of. Uh, frame this more as a foundational episode within the cell danger response. And so in order to do that, we need to take you [00:01:00] guys through the history of cell danger response, going all the way back to Robert Navio from University of California, San Dia, San Diego.\n\nBoomer Anderson: I almost said San Diego, which is actually the Ron Burgundy way of saying San Diego. Uh, but in order to do that, I have to invite somebody into this conversation, Dr. Ted. Uh, you're the one who brought us the rich work of Robert Naviaux. What the hell is the cell danger response? Who is Robert Navio? Why should we care?\n\nDr. Ted Achacoso: Well, uh, Robert Navio is of course a physician scientist at um. At UCSD as you said. And, uh, he created a framework that was published actually in 2013 and 2014 actually in the mitochondrion. And that was a time where I was actually very, very actively, uh, doing, uh, a lot of lecturing about mitochondria.\n\nDr. Ted Achacoso: Right? And then when he came out with this framework and, uh, you know, looking at [00:02:00] health optimization medicine and practice. I saw that the framework is actually, uh, a very much evolutionarily conserved, um, mechanism of the cell in order to protect itself. So in other words, why other words, when it's threatened?\n\nDr. Ted Achacoso: It'll always protect itself one way and then it'll resolve, uh, itself, right? So it's a very beautiful, uh, and, and well conserved, uh, mechanism. It's not a disease, right? It's just a framework for looking at how the cell actually protects and adapts itself evolutionarily to certain threats. For example, physical threats, chemical threats.\n\nDr. Ted Achacoso: Infections like viruses, and you're looking at this from a single cell, right? You're not looking at this from a personal level. What does a cell do when it's actually threatened by all of this? And, and of course, uh, they also found out like, you know, psychosocial stress. Right. Uh, those, for example, the stressful separations of divorces could actually activate the cell danger [00:03:00] response.\n\nDr. Ted Achacoso: And, uh, since I've known to joke about, you know, uh, removing toxins in your life, it's, uh, including the removal of toxic partners, you know, uh, by looking at it from the cell danger response lens, it's certainly not, uh, you know, uh, a farfetched, uh, uh, joke anymore. Uh, so when you look at the response there, actually.\n\nDr. Ted Achacoso: Uh, the basic premise is this is a survival mechanism, right? So protection first before anything else. So we protect itself against all fats. So, so that's the underlying part. And then, uh, so. So when you're looking at, uh, now you proposed like, uh, three, uh, different, uh, cell danger responses, right? Cell danger response one, right?\n\nDr. Ted Achacoso: Would be to contain, to contain the damage, right? You are not repairing the damage yet. You're just containing it and you're defending yourself from it. Right. So, uh, so at this, how, how does the body do that? And, you know, the first defense of the body is actually [00:04:00] to inflame, right? So you, you see a lot of inflammation and, and so on.\n\nDr. Ted Achacoso: And then, and then the second part will be, so that will actually, uh, when, when left, right, when left to, to, to heal the body is actually healthy, the body will go into a stage called, um, uh, CDR two or Cell Danger response, uh, stage two. Right. And this is marked by what's called, uh, uh, proliferation and Repair, right?\n\nDr. Ted Achacoso: The body produces, uh, you know, a lot of cells, a lot of scaffolding. It rebuilds, right? In other words, it starts building the beginning, the process of repair and so on, and then. The, and then when that is done and actually, uh, heals, uh, uh, properly, then it goes into, uh, CDR three, right, where everything is actually, uh, reintegrated, uh, and, and, and, and, uh, in a fully functioning system.\n\nDr. Ted Achacoso: So this is actually mirrored and this is, uh, very, very much fun for me because [00:05:00] I love my deondra, right? Uh, like for example, when you're looking at stage one. The, the, the, the mitochondria are fragmented. Like they go, well, fuck you. I'm not going to share my energy with you, whoever you are. Invader, right?\n\nDr. Ted Achacoso: I'm going to decrease my, my, um, my, uh, uh, uh, energy output, you know, because I am not going to, to let you take charge of this and actually use up this energy. Uh, so it's a, it's a defense mechanism, right? Uh, the, the. Mitochondria, uh, does, and then the second thing that the mitochondria does is why it's the center of all of this, right?\n\nDr. Ted Achacoso: It's like, is that it actually releases, um, uh, a TP. So inside the cell, you know. People have an imbalance view of mitochondria. They think it's only the batteries for your cell, but actually that mit, the, the mitochondria, when, when they're actually sensors, right? They sense what's going on. That's how you're actually linked to your environment, right?\n\nDr. Ted Achacoso: It's like, it's like they sense a lot of things that are going on and then once they're stressed out, what they do is that they release [00:06:00] a TP and that a TP now does a release outside the cell, becomes basically a dangerous signal. It'll warn the cells via, Hey, hey, hey, you know. There's a, there's a stressor going on, right?\n\nDr. Ted Achacoso: My ex is coming to visit or something like that. So, but, but anyway, uh, so that, that's what's called energic signaling, right?\n\nBoomer Anderson: Help me. Help me.\n\nDr. Ted Achacoso: because, because it's, it's a, it's a, or it's Thanksgiving and. God dammit, my enlightenment is gonna get tested. So, um, so you're, you're, you're, you're basically looking at it.\n\nDr. Ted Achacoso: Uh, that's the second charact mitochondria is a biosensor. The second thing, it's very reliant on periodic signaling right outside the cell. You know that a TP becomes a warning. It's just like. A flare, right? It's like whining to all cells. There's stress going on, and the body is actually to, to, uh, actually convert it now to, to a DP, to a MP and then a Denison, which now quells that, uh, that, that flare for you.\n\nDr. Ted Achacoso: Right? Um, and that's why in his experiments, the, the [00:07:00] classic, uh, experiments that he actually said there was the use of serum, which is an antipurinergic in autistic cases, right? And he presents, uh, those, uh, in, in the paper also. so if, if you took a take, take a look.\n\nDr. Ted Achacoso: Mitochondria Stage two, since it's proliferative stage about repairing, they're non-committal, right? So in, in the first one, they're called stage what's called M1, right? And, and for those mitochondria geeks out there, it's M1, it's like they're fragmented, et cetera. This M zero is basically non-committal.\n\nDr. Ted Achacoso: Yeah, yeah. We're proliferating. So we're just dividing and dividing and then putting it in all different cells that it has to, to, to, to function, right? Because you destroyed a lot of them. And then the um. The, so, so at one M zero and then the mitochondria on, on, uh, CDR three becomes, you know, uh, M two, right?\n\nDr. Ted Achacoso: And M two is a full filamentous producing oxidative phosphorylation and so on. So, so here's, here's like the difference. This is beautiful because it's sequential and it actually, for me, guides the clinician [00:08:00] on what you can do and cannot do during these stages, right? So, uh, for example. Uh, what, what is the most interesting for me is that a clinician, uh, when looking at these different, uh, stages, right?\n\nDr. Ted Achacoso: Of course there are no, there are no specific indicators that will tell you, oh, he's, he's at, uh, the stage is he's stuck at this particular, uh, uh, uh, stage right of the CDR resolution. So in the self danger response, what is important for the clinician is like. Where is your patient or your client stuck?\n\nDr. Ted Achacoso: Right? It's it because it's like this sequential, uh, uh, process will actually, you know, naturally run its course, but what usually happens is that it gets stuck. So what happens when you're stuck at CDR one? What happens when your AKA CDR two? What happens in AKA CDR three and A Actually, it begs the question right?\n\nDr. Ted Achacoso: What can [00:09:00] you do to actually, uh, uh, you know, optimize the resolution of those particular stages? And the other thing that's has to be asked also is like, what should you not fucking do? Right? Uh, in, in, in those particular, uh, stages. And you know, Jodi will be. Taking care of, you know, what you can, uh, probably look at and when you're stuck at different stages.\n\nDr. Ted Achacoso: But an example that I can give is that, you know, in, in CD R one, for example, when you're stuck in there, right, the body, the, the cell is actually saying, I am going to purposefully decrease my oxidative phosphorylation, right? So I'm not going to produce energy for you guys. You know, it's, it's like, no, it is like my energy is going to be sent out and warn others, right?\n\nDr. Ted Achacoso: A TP is going to be for production and then what do you do? Right? Like the, the cell is reducing reactive oxygen species, you know, to bump up the inflammation. And this is to fight right to. For defense and then what you do. Oh, let me give you a lot more antioxidants. Well, the census says, fuck you, you are not helping me here.\n\nDr. Ted Achacoso: You know, I, [00:10:00] I am, I am actually trying to, to help defend myself with lots of oxidation. Right. And that's why, for example, hyperbaric oxygen therapy, for example, would be good for, for CDR when you're stuck in, in CDR one because it actually helps fight the, the, the condition. Right. Um, but it's, it's not, it's\n\nBoomer Anderson: meth. We were talking about methylene blue earlier too, right? Like potentially.\n\nDr. Ted Achacoso: Yeah. So, uh, you, you, when you, yeah, when, when, when you give methyl in blue, of course it will try to rev up your electron production, right? No. You give methyl in blue when you're, you're stuck in, in CDR three, right? So, uh, but remember this is a sequential mode, but your body, the different cells from your body, and this is the, the complicated part of it can be stuck in different parts of it.\n\nDr. Ted Achacoso: Right. So now we can hear from Jody what happens when you're stuck in this because this is what the clinician should remember. It's like, how, what hap, what do you see when you're stuck in any of these stages? And how do you unstick them? Right? Uh, what can you unstick them and what should you not do [00:11:00] to unstick them?\n\nDr. Ted Achacoso: Right?\n\nBoomer Anderson: Yeah, let, let's first, I want to take this in terms of like phenotype, right? And Jody, you see this coming into your clinic often when you, when a client presents themselves, ha has a whole bunch of stories, whatever. How do you identify just sort of different stages, the CDR, and you know, what does that kind of.\n\nBoomer Anderson: Look like for you as a clinician in terms of what you can do.\n\nJodi Duval: Oh. So I think it's also good to understand it from a point of view of, um, when we're sick as well. So when we're looking at, you know, fevers and, um, when we're in that sort of prime defense mode, as Dr. Ted was saying, I think it's, it's it, for me, it's a better understanding when we understand like the evolutionary point of view of why we actually got into that fever.\n\nJodi Duval: It's primary defense. And so what we do wrong in those stages is. The point of interacting or, or, um, intervening too early. And I think that is particularly true for CDR one. Um, and like you were saying, [00:12:00] Ted, it's, it's defense. So what I see in these clients particularly is that their inflamed, their CRP or H-S-C-R-P is up, their ESR is up, they have, um, higher lactate.\n\nJodi Duval: So we can measure this in the organic acids. We've got histamine patterns and lower, um, you know, heart rate variability as well. They have headaches, skin flares, um, brain fog. Um, they're overly, they're, they're overwhelmed, they're really sensitive. Um, and the body is crying out to be supported and not be restricted, um, be supported to, to signal correctly, to work with what it can see, and to eventually lead into that CDR three and resolution.\n\nJodi Duval: So when I see. Clients mainly in CDR one, like you were saying, Ted, I think the most important part that they do wrong is, is by either fasting, um, under nourishing, by adding too many antioxidants by actually trying to [00:13:00] quell a process or put the fire out before the fire had a chance to do what it needs.\n\nJodi Duval: To do. And so these are the most important parts I see in in clients. And so sometimes I celebrate some of the reactions that they get because you know that there has been a start again to the process of RESO resolution. And so, you know, sometimes they get stuck into. Um, CDR two, and then you actually have to go back to CDR one again to then get back into the resolution pathway.\n\nJodi Duval: And so that's where I, I find it can be quite, um, uh, exciting for clients when they go, oh, I feel achy and sore and inflamed, and I've had a flare up of my skin again. I'm like, great. We are back to this process and let's complete this now. Let's complete this cycle. \n\nBoomer Anderson: No, I, I think. That's a, just like such a good point to emphasize, right, is that sometimes the reaction is actually a good thing. Uh, and because oftentimes as clinicians, uh, and particularly, uh, you have a client who might wanna be on all the time and you know, they have this sort of flare up, this reaction, [00:14:00] those types of things that you just highlighted, and as a result they think it's a completely negative and they might have fit.\n\nBoomer Anderson: See it as like a failure in their health optimization journey, particularly the types of people that I deal with. Whereas this is actually showing you the sign that the body is responding correctly. Right, and I think there's such a key point that I wanted to reemphasize there.\n\nDr. Ted Achacoso: Well, uh, that actually, uh, sorry, Jody, I just wanted to, to piggyback on what Boomer said, uh, because you know, as I said, we view things. Is different in home hope. And, uh, I was just proposing really, uh, the way you look at diseases are these are just like the phenotypes of stalled CDR uh, uh, stage, right? So for example, if you're looking like an asthma, you know, uh, or.\n\nDr. Ted Achacoso: Uh, flu like malice or all of those kinds of things, these are just phenotypes of a stalled CDR one, right? So, uh, so that's how we look at diseases. They're, they're adaptations, but they're mal adaptations. So diseases are not [00:15:00] independent entities of themselves, but rather become the, a stalled phenotype, uh, of, uh, a cell dated response, right?\n\nDr. Ted Achacoso: So anyway, uh, please, Jody.\n\nJodi Duval: So, you know, from that CDL one point of view, and for all of them actually for the stages, you, you, your questions that you have to ask is, well, what does the body need at this particular time? What do, what, what is it requiring of us? Um, and I think they're really important questions that we ask. It's not always, um, what do I give or what do I supplement or, um, what do I need to add in?\n\nJodi Duval: Sometimes we actually need to remove, so at this particular c DL one stage, I look at the exposomes. Um, infections, you know, is there anything that we need to lessen the load on the body to support it, to actually do what it needs to do? You know, those\n\nDr. Ted Achacoso: And that's the fundamental part of it, right? You have you remove if you're go, if you're being attacked, well first you have to remove the attacker, right? So.\n\nJodi Duval: Yes. Exactly. Exactly. And I think we [00:16:00] always look, you know, and not by overdoing it either. Sometimes we, if we aggressively use antimicrobials at the wrong time, you know, it's not always the thing that the body needs. It's something that it actually needs to have the signals of them to then create its responses and then to, um, get into completion, completion stage as well.\n\nDr. Ted Achacoso: Yeah. Yeah. That's why exosomes is so important, right? Because mold, mold can actually push you into CDR one. Right. Uh, and then, and then after your, your, your patient moves away or goes away on and lives somewhere where there is no mold and everything else, and then fit to a place where it was with the molds and everything else.\n\nDr. Ted Achacoso: And you see, of course, the, the resurrection of, uh, uh, all of this, uh, of particular, uh, stages. And initially because a patient is healthy, you know, they will, uh, be able to successfully go through the different stages of resolution. And then you will see as the body's resources get depleted, they will get solved.\n\nDr. Ted Achacoso: Right? So. Anyway.\n\nJodi Duval: Mm, absolutely. And that's where I think, you know, even when we're looking at EMF [00:17:00] and anything else that is destabilizing the nervous system and, you know, for this CDR one aspect, we need to actually look at the nervous system and supporting it. So it has, um, time and space to actually repair, you know, to go into that repair, you know, rest, digest, and repair.\n\nJodi Duval: Needs to be into that stage one to then go into that completion for the stage three. So yeah, that, that stage one, um, I see repeating often in clinic, um, without actually coming through into even the stage two and three. But then in stage two or in CDR two, we see a lot of the chronic, chronic complex sort of plateauing patients.\n\nJodi Duval: And this is where, um, you know, you see a huge shift in the, in the microbiome, the dysbiosis we see. Hormonal patterning. We see weight resistance, you know, MCAS and fatigue and this, you know, fibrotic conditions. We also see, you know, endometriosis and even\n\nDr. Ted Achacoso: And the big thing this, since this, the big thing, Jo, this is [00:18:00] proliferative cancers, right? Uh, this is the work of the work of, right, uh, in terms of, uh, you of uh, basically, uh, uh, queing the Warburg effect, right? Uh, by, by using ketones, uh, for example, right? And, and ketogenic diets for, for metabolic causes of cancer.\n\nDr. Ted Achacoso: And it's, uh, being stuck at the CDR two level. So that's the, the big scene there for those that are, uh, you know, that are, uh, you know, uh, pet positive, for example, that the cancer cells actually are using glucose, you can actually starve. Right. Uh, by, by, by, uh, giving ketones and genic diet. So, and that's why it works by the way, it won't work for all cancers.\n\nDr. Ted Achacoso: Right. And, uh, because some cancers are actually the, um, uh, the metabolically, uh, the one that you could trace, uh, the metabolic origins of are actually stalled CDR two. And that's what I mean, that like. This cancer is installed, uh, most cancers installed CDR two phenotype. So, uh, and that's what I mean by that.\n\nDr. Ted Achacoso: And, you know, [00:19:00] diabetes, uh, heart disease, et cetera. This, this, all this all fall in a stalled CDR two. And that's why it's important for the clinician to actually know what gets, what, what happens when something stalls, right? Uh.\n\nJodi Duval: Absolutely. And then you have, you know, that when we look at the summer winter of the CDR, we are looking at this as being the, you know, anabolic, um, you know, stalling and that sort of, that drive. So we're looking at insulin, we're looking at IGF one, we're looking at, um, even the fatty acid imbalances in the, in the oats and, um, you know, the, the citric acid cycle.\n\nJodi Duval: Um, but really with that dysbiosis, I think it's key here. This is where I see a lot of clients in this chronic gut dysbiosis or gut. Issues. And so looking at, um, supporting them through this process as well, you know, obviously we don't jump into optimization prematurely here either. I think we're, we're, we have to still remain in the point of view of like assisting the body.\n\nJodi Duval: What do we need to do? What is it asking of us? [00:20:00] Guided, structured, repair, you know, correcting imbalances here. Um, you know, rebuilding some of the systems, we are really looking at motility and bowel flow and gut function. We are looking at hormone balancing and correcting ratios.\n\nDr. Ted Achacoso: I was actually going to mention that this is, this is, uh, stall CDR two. Is where hormone balancing does a lot of its magic, right? If you could, so, and that's why you see, uh, patients or clients that have, you know, chronic diseases like chronic heart disease, you know, uh, um, uh, cognitive decline and all this, uh, other, uh, chronic diseases, uh, diabetes and, and so on.\n\nDr. Ted Achacoso: You could see that, um, chronic neurogen, new degenerative diseases. I said, uh, neurodegenerative. Diseases, uh, is that they would actually respond to these types of, uh, of management, right? And is that, that's why you have, you get the biggest, a big, I do get a big bang of the, for the back of, uh, doing hormone balancing for these people because you know that that's a stalled C two, uh, [00:21:00] phenotype, right?\n\nDr. Ted Achacoso: Uh, this chronic. \n\nJodi Duval: And I think so many, uh, you know, so many people within the population fit into this CDR two, um, stalling, and that's what's scary. I feel like you could. Go, um, for years and years and years and years within this particular CDR two and not have, um, any, any diagnoses or any corrections, and that's a very dangerous place to be.\n\nJodi Duval: Um, and so, you know, moving on, so we don't sort of. Hold, hold up the podcast, but, but phase three or, or CDR three, you know, you're looking for more of that. It's completion. It's like the body's gone. Yes. I've gone through the cycle. I can see the light at the end of the tunnel. I am almost there. I am reaching resolution here.\n\nJodi Duval: And\n\nDr. Ted Achacoso: But wait, I can stall you some more.\n\nJodi Duval: Yeah, but, but, but be careful because we, we are still not quite there yet. Um, so what we're looking at here is mitochondrial efficiency, adaptive [00:22:00] capacity. We're looking at anti-inflammatory. So we're looking at all the signaling that is, that should be working and correcting and be stable and resilient and more responsive.\n\nJodi Duval: So you're seeing. You know, little bits of, of, of positive movements forward in your, in your clients and your patients. So better recovery, your sleep, the mood stability, all these things. And, um, uh, you know, HRV is improving as well. So here we can start to really dive into more of the optimization. We can really start, this is where.\n\nJodi Duval: Where we can now go, okay, this is where health optimization should, um, now begin. Almost, you know, we've helped and supported the rest of the cycles, but now we can actually really dive into this and, and elevate our clients and build that performance and longevity in here. \n\nDr. Ted Achacoso: Well, we've already begun health optimization by assisting in the resolution of the cell dangerous\n\nDr. Ted Achacoso: one. Right? So, so we, we, we, we've done the hard part, right? And now the, the part of health optimization, that's, that's, uh, you know, uh, uh, where we shine in [00:23:00] terms of taking care of the cell now because we've taken.\n\nDr. Ted Achacoso: The, the, the, the, uh, taking care of facilitating the resolution of the different, uh, sage cell danger response stalls in, in any one of them. As I said, you know, it's the stall world word that you have to remember. Right. And as Jodi said, you know, um, when CDR three is arrested, then you have like, you know, chronic fatigue, right?\n\nDr. Ted Achacoso: You have, uh, postex, successional malice or you know, um, postex successional symptom exacerbation. These are very well known things. In, in, uh, in, uh, my of. Is right or chronic fatigue syndrome because the body cannot produce. If it's still there, then it cannot, it's oxidative for circulation. Mitochondria cannot contribute to the, uh, uh, to the energy, right?\n\nDr. Ted Achacoso: So, and you know, here comes, uh, you know, a gym instructor is saying, now you gotta push. It's like, what the fuck? You know, I don't even have energy because, uh, your, your patient or client's actually stalled in CDR three. So it's very important to know [00:24:00] where your patient's stalled and then now what you can do, uh, to.\n\nDr. Ted Achacoso: To, uh, to use it. And this is also where boomer's favorite part of actually wearing these wearables and, you know, to monitor your sleep and, and to do this. The HRV, you know, uh, boomer and I were just talking about this this morning. Like, oh, my HRV jumped by, you know, expert stamp. \n\nBoomer Anderson: \n\nDr. Ted Achacoso: uh, you could see here that this is where the payoff of those, you know, um. Uh, uh, personal measurement, uh, actually, uh, would, would help you in terms of moving, uh, towards the resolution of CDR three. Sleep is a very important, uh, contributor. In fact, in fact, it's one of the things that's consistently aside from removing the threat in general because this is a life preserving, um, uh, strategy, uh, or framework of the cell, right?\n\nDr. Ted Achacoso: This is a life, life preserving. Uh, framework for the cell. What it does is that, okay, you remove the threat first, but it also looks for the [00:25:00] regularization of your rhythms, right? That's why you could see that. As you go progress through your, uh, your, uh, facilitating the resolution of the cell data response in terms of, uh, them being stalled or actually optimizing their resolution.\n\nDr. Ted Achacoso: You'll see that once sleep regular rises, you will also see that the, uh, the, the, your patient or client is actually getting healthier. Right. Uh, uh, and, and, and not having all of this, oh, I'm, I'm fatigue all the time. You know, I'm, I'm, uh, having all of this, uh, uh, you know, and in, in fact, if you do this properly, uh, I have watched personally, uh, you know, watched, uh, uh, people with, uh, uh, lupus diagnosis, right?\n\nDr. Ted Achacoso: And they're relying on their, uh, a NA markers and so on. Right. We, you know, without doing anything right, uh, just by doing the balancing that you need to do, and being mindful that they are stuck in CDR three, right? You could see that there, uh, that their, their ANA markers are [00:26:00] just start plummeting downwards.\n\nDr. Ted Achacoso: Right. And this is over a course of time, remember? Um, because, uh, we have to be patient. You know, the, the cell is both a digital and an analog system, but it's mostly analog because everything is done by, by the cytosol, right? Uh, so, um, so these are the kinds of things that are, are really. Um, are helpful for the condition where you're stall, you know, CD R one would cost you information.\n\nDr. Ted Achacoso: If you're, you, you can get stall in there. CD two will cost proliferation. If you're stall in there, CD R three would actually, uh, cause you, uh, decreased energy, right? Uh, if you're there able to, to move forward. So you could see there that, uh, each of this is actually all geared towards surviving an attack, whether the attack is physical, uh, chemical, um, uh, infectious.\n\nDr. Ted Achacoso: Or, uh, or, uh, psychoemotional, right? So, so you could, you could see there that, uh, all, all of this, I, and the important thing about this, [00:27:00] as Jodi actually said, is that the body does this in sequence. You cannot skip a step, right? Uh, and when you're stalled in one, she already mentioned like, uh, ho, holy shit, I can't get you there.\n\nDr. Ted Achacoso: Let me bring you back to stage one and let's do this all over again. So, um, and, and, and, and that's now, you know, and that's now the hallmark of a master health optimizer, like Jody, right? So she's like, okay, you know, that didn't work. Let's do it this way because we now know what the pathways are in terms of how this, the, the, uh, uh, self protected cell.\n\nDr. Ted Achacoso: Remember, this is a survival mechanism. Right. The, the two fitness functions for us in evolution is survive and reproduce. And as I always say, reproduction is just another form of survival. So when you're looking at this, you're looking at the cell actually trying to defend itself from something or trying to survive.\n\nDr. Ted Achacoso: If you are, the, the main picture here is imagine a, a child that's scouring from fear over some [00:28:00] whipping that it's taking right. And then you say, here, eat is chocolate. No, the child won't eat it, right? It's because like, no, no, no, no, no. I have to, to make sure that this person who's whipping me goes away first.\n\nDr. Ted Achacoso: Right. So, so, and that's the way you take a look at this is you have to remove the threat first. And the third is usually, um, uh, in the exposome. And that includes your, I said your relationship with toxic people is part of your exposome. So. And so, and that's the way I, I think about this is like, are you really going to have a feast?\n\nDr. Ted Achacoso: Right? When, when, when, you know, um, well if you're, you're neuro, I suppose you can play your fiddle while Rome is burning around you. But, uh, but you know, the cells are not neuro, so they will actually cower and they will isolate themselves, right?\n\nBoomer Anderson: I didn't Ula have that problem too? I don't know. It wasn't just a mirror thing.\n\nDr. Ted Achacoso: No, I, I, I love k Gira for different ways. You know.\n\nBoomer Anderson: Yeah, yeah. Anyway, that's another subject. I think [00:29:00] incest is another subject. Um, so, uh, perhaps CDR two with incest. But, um, anyway, uh, I want to kind of wrap this up guys 'cause we're coming up on that dear time thing.\n\nDr. Ted Achacoso: Oh, oh, oh, wait. Boomer, you said a word. Incest. Incestuous, uh, CDR is when you're mixing them, right? Like, for example, you go on a five day drug binge, right? You take all of these drugs for five particular days, you're actually going to induce CDR one c, CDR three, all at the same time, both at the same time.\n\nDr. Ted Achacoso: Right? But that's induced by you, right? So, so that's incestuous, uh, uh, cdr, right?\n\nBoomer Anderson: Ah. There you go. There you go. So we\n\nBoomer Anderson: learned something. you can have one and two, you can have two and three, you can have one and three, right? So all of these can go together, but that, that's the thing. That's the, that's the, uh, the body's not a mosaic though, right?\n\nDr. Ted Achacoso: It's not an inces mosaic. The body's actually one coordinated system. But you will see the manifestations of all of those mixes [00:30:00] in what predominant part is actually manifesting. Right. For example, if you go on a, on a drug binge say, say five days straight, right? And you will see that there's actually weakness.\n\nDr. Ted Achacoso: Uh, uh, at at the end. Because say you're an expert at quelling inflammation and you can quell all inflammation all you want, but your body at the end of five days will still not be able to produce that a TP that it actually needs, right? Because you actually all use this up in order to warn all the other cells, like, Hey, you know, boss is stressing us out again.\n\nBoomer Anderson: Boss is on a bender. Awesome guys. I, I know there's so much to unpack here when it comes to CDR and concluding, you know, favorite tips and tricks to quell the CDR in various stages. But I think that's subject for another episode. I need to ask one of you to wrap us up and kind of give summary three points as to why we should care about the CDR as it relates to health optimization medicine.\n\nDr. Ted Achacoso: Okay. Okay. Let me do that. Health optimization medicine [00:31:00] practice, you think of it as this umbrella framework, right? That subsumes the cell danger response as. The major thing that it takes care of for you. Right. And there are three things that, that, the word that you should remember, uh, in here is that it's about survival, right?\n\nDr. Ted Achacoso: The cell wants to survive, so it'll do everything that it, it needs to do in order to protect itself, to repair itself, and to bring itself back to functioning. The clinicians, um. Uh, word to remember is stall. Where do this cell danger response stages stall, right? And questions ask, what can you do right to install it?\n\nDr. Ted Achacoso: And what should you not do to install it? Because all of this have different requirements, right? The mitochondrial, uh, uh, morphology and functioning are different for all of these states. And remember that. Uh, it uses, uh, the, the, the last word to [00:32:00] remember this is all actually mitochondria driven. And the way you look at mitochondria should be as sensors, biosensors of the environment, not just batteries for yourself.\n\nDr. Ted Achacoso: Right. And the other, the, the second term that you will hear a lot, uh, a lot when you're looking at sage responses was called puric signaling. Right? So, uh, and if you don't know what to do, and you don't know about what the fuck the CDR is and so on and so forth, do what you would do naturally when you're under threat, right?\n\nDr. Ted Achacoso: You remove the threat. Right. So if you're under high mercury, you know, levels, et cetera, et cetera, well, what the fuck? Just get rid of the threat, right? It's the first thing that you do. Get rid of the exosome threat, right? Remove the cell from danger. That's why it says danger response,\n\nBoomer Anderson: If you're on fire, you don't cook dinner at the same time. Right.\n\nDr. Ted Achacoso: no, and, and that's why many people actually, uh, go from CD stalls, [00:33:00] CDR one, right? And then they get stalled at, uh, CDR two because, you know, they're unable to remove the threat of their, uh, toxic spouses. So, I'm kidding. I'm kidding. But it's a way to take a look at removing threat, right?\n\nDr. Ted Achacoso: How do you remove threat? And, and, and, and, and, and again, when you think in evolutionary terms, uh, you know, you should think of. how the body, uh, how the cells, uh, and the body and everything else around it will actually be, performing in an environment where there are both, predator and prey, right?\n\nDr. Ted Achacoso: Something that threatens you and something that won't. So that is a basic principle. The body will have, uh, the cells will have that same way too, how it'll protect yourself from something that's threatening their own survival. Because remember, fitness function is only two things in, in our species and in many species, right?\n\nDr. Ted Achacoso: It is survival and reproduction. So know your CDR stages. Uh, [00:34:00] uh, there are many, many, many details. This is just, you know, uh, the tip of the ice cream. Uh, so, um, it's delicious. When you poke inside, it's a lot more delicious, especially for clinicians to be able to actually see, you know, that a lot of the, um, a lot of the interventions that you do for your clients make sense and why they don't make sense.\n\nDr. Ted Achacoso: At certain parts of your, uh, uh, of your handling a client or why they don't make sense for certain clients is because. If you get a better handle on all of the details of this, then uh, uh, you know, you, you, you, uh, then you will be able to, uh, optimize the health of your, uh, clients or patients a lot more.\n\nDr. Ted Achacoso: So in health organization medicine, you know, this is discussed in, uh, module called Evolutionary Medicine. And many people ignore it, right? Uh, because it's like, eh, what the fuck is it? You know, evolutionary medicine, et cetera. But this is exactly it. You know, this is exactly the module that [00:35:00] says that diseases are just, uh, you know, uh, a phenotype of a stall, uh, uh, CDR, uh, stage, right?\n\nDr. Ted Achacoso: So, uh, and that's, that's how I would, uh, summarize, uh, this, uh, uh, brief introduction to the Sal Danger Response.\n\nBoomer Anderson: All right. Uh, Jody, Dr. Ted, thank you so much for joining us here tonight. This has been another episode of the Health Optimization Medicine Podcast, soon to be named The Cell Danger Response Podcast. Maybe, I don't know, uh, but for those of you tuning in tonight or this day, wherever you're watching this, uh, please, if you're watching this on YouTube kick, like subscribe, leave a comment.\n\nBoomer Anderson: Let us know what you think. Other episodes you want us to kind of dive into is also appreciated. If you're listening to this on Apple Podcasts or Spotify, uh, give us a fast star rating, a comment, please. 'cause those things go a long way in this algorithmic world. To everybody listening, always choose Huff.\n\nBoomer Anderson: Thank you.\n\n

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Health Optimization Medicine Podcast

The Cell Danger Response Explained (Why You’re Not Healing)

April 15, 2026